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Estradiol is responsible for the regulation of the estrous and menstrual female reproductive cycles and for the development and maintenance of female secondary sex characteristics.^3,4 Estradiol plays a key role in germ cell maturation and numerous other, non−gender-specific processes, including growth, bone metabolism, nervous system maturation, and endothelial responsiveness. Estrogens are crucial for the normal development and maintenance of the breasts and the uterus.⁵ However, excessive estrogen levels can promote cell proliferation and may increase the risk of developing breast and uterine cancer as well as uterine endometriosis.⁵